Medication Therapy

There are various medications used in the treatment of enlarged prostate or Benign Prostatic Hyperplasia (BPH).

Alpha Blockers, 5 Alpha-reductase Inhibitors and Phosphodiesterase-5 inhibitors are prostate drugs used in the treatment of BPH. These drugs, which have different action mechanisms, can sometimes be used together (combined).


Alpha-blockers are a group of drugs that relieve the patient’s complaints and urine flow by relaxing the smooth muscles of the prostate. It is the most recommended drug group for men with BPH. Alpha-blockers do not reduce the size of the prostate or prevent it from growing. Alfuzosin, Doxazosin, Tamsulosin, Terazosin, Silodosin are the drugs in this group.

The side effects of alpha blockers are mild, and most patients do not experience any side effects, although they are used for a long time. The most common undesirable effects are dizziness, weakness (asthenia), dizziness and low blood pressure. Alpha-blockers can also cause retrograde ejaculation (emptying of semen into the bladder). This is an uncommon side effect and will disappear when treatment is stopped.

5 Alpha-reductase inhibitors

5 alpha-reductase inhibitors (5-ARI) are a group of drugs that can prevent enlargement of the prostate and even cause it to shrink in the long term. These drugs are more effective if the prostate volume is greater than 40 ml. When used long term, it may reduce the risk of urinary retention and the need for surgical intervention.

There are two types of 5-ARI: Dutasteride and Finasteride. Side effects of these drugs are mainly on sexual functions. It can cause decreased sexual desire, erectile dysfunction (erectile dysfunction) and ejaculation problems. Side effects are not very common and disappear upon discontinuation of treatment. Due to its potential side effects, 5-ARI is generally recommended for patients with moderate or severe symptoms and large prostate size (> 40 ml).

Phosphodiesterase 5 inhibitors

Phosphodiesterase 5 inhibitors (PDE5-I) are drugs used in the treatment of erectile dysfunction. There are 3 types of PDE5-I: Sildenafil, Tadalafil and Vardenafil. In addition to treating erectile dysfunction, these drugs can also improve symptoms associated with BPH when used regularly.

NOTE: The content of the page is for informational purposes only, consult your doctor for diagnosis and treatment.